abstract：BACKGROUND AND OBJECTIVE:Numerous autoimmune diseases (AIDs) have been linked to chronic spontaneous urticaria (CSU). Here, we provide the first extensive and comprehensive evaluation of the prevalence of AIDs in patients with CSU and vice versa. METHODS:A Pubmed and Google Scholar search was performed to identify stu...

journal_title：Autoimmunity reviews

authors： Kolkhir P,Borzova E,Grattan C,Asero R,Pogorelov D,Maurer M

更新日期：2017-12-01 00:00:00

abstract：:Despite the improvement in the quality of life of patients with SLE due to scientific and technological advances, SLE remains a disease that over the years may produce irreversible damage to patients. Osteoporosis and secondary bone fractures are two of the major causes of irreparable injury in patients with SLE. Vita...

journal_title：Autoimmunity reviews

authors： Salman-Monte TC,Torrente-Segarra V,Vega-Vidal AL,Corzo P,Castro-Dominguez F,Ojeda F,Carbonell-Abelló J

更新日期：2017-11-01 00:00:00

abstract：:Systemic sclerosis (SSc) or scleroderma is a disorder of the connective tissue affecting the skin, and it is often associated with visceral involvement. The predominant pathological features of SSc are autoimmunity, vasculopathy, and fibrosis. Progressive fibrosis is associated with changes in the microcirculation of ...

journal_title：Autoimmunity reviews

authors： Rossi D,Zanatta E,Marson P,Sciascia S,Polito P,Roccatello D,Cozzi F

更新日期：2017-10-01 00:00:00

abstract：:This Special Issue of Autoimmunity Reviews constitutes summaries of presentations at the 20th International Meeting on Immunopathology and Orphan Diseases, held in Torino, Italy, 25-28th January 2017. As such, these presentations represent the state of the art on the pathophysiology of autoimmune diseases as well as t...

journal_title：Autoimmunity reviews

authors： Roccatello D

更新日期：2017-10-01 00:00:00

abstract：:While the relationship between maternal connective tissue diseases and neonatal rashes was described in the 1960s and congenital heart block in the 1970s, the "culprit" antibody reactivity to the SSA/Ro-SSB/La ribonucleoprotein complex was not identified until the 1980s. However, studies have shown that approximately ...

journal_title：Autoimmunity reviews

authors： Izmirly PM,Halushka MK,Rosenberg AZ,Whelton S,Rais-Bahrami K,Nath DS,Parton H,Clancy RM,Rasmussen S,Saxena A,Buyon JP

更新日期：2017-09-01 00:00:00

abstract：:Autoimmune diseases are a complex set of diseases characterized by immune system activation and, although many progresses have been done in the last 15years, several unmet needs in the management of these patients may be still identified. Recently, a panel of international Experts, divided in different working groups ...

journal_title：Autoimmunity reviews

authors： Giacomelli R,Afeltra A,Alunno A,Baldini C,Bartoloni-Bocci E,Berardicurti O,Carubbi F,Cauli A,Cervera R,Ciccia F,Cipriani P,Conti F,De Vita S,Di Benedetto P,Doria A,Drosos AA,Favalli EG,Gandolfo S,Gatto M,Grembiale R

更新日期：2017-09-01 00:00:00

abstract：:Myocarditis is a major cause of heart disease in young patients and a common precursor of heart failure due to dilated cardiomyopathy. Some auto-immune and/or auto-inflammatory diseases may be accompanied by myocarditis, such as sarcoidosis, Behçet's disease, eosinophilic granulomatosis with polyangiitis, myositis, an...

journal_title：Autoimmunity reviews

authors： Comarmond C,Cacoub P

更新日期：2017-08-01 00:00:00

abstract：:Endothelial dysfunction and microvascular damage constitute the hallmarks of systemic sclerosis (SSc), explaining much of the pathophysiology and clinical manifestations of the disease. Nailfold videocapillaroscopy (NVC) is an established method for the assessment of the microvasculature, aiding in distinguishing diff...

journal_title：Autoimmunity reviews

authors： Soulaidopoulos S,Triantafyllidou E,Garyfallos A,Kitas GD,Dimitroulas T

更新日期：2017-08-01 00:00:00

abstract：:Survivin is a protein functionally important for cell division, apoptosis, and possibly, for micro-RNA biogenesis. It is an established marker of malignant cell transformation. In non-malignant conditions, the unique properties of survivin make it indispensable for homeostasis of the immune system. Indeed, it is requi...

journal_title：Autoimmunity reviews

authors： Gravina G,Wasén C,Garcia-Bonete MJ,Turkkila M,Erlandsson MC,Töyrä Silfverswärd S,Brisslert M,Pullerits R,Andersson KM,Katona G,Bokarewa MI

更新日期：2017-08-01 00:00:00

abstract：:Disorders of peripheral nervous system in patients with systemic lupus erythematosus (PNS-SLE) are a major cause of morbidity. The aims of the present study were to determine the prevalence of PNS-SLE involvement in a large cohort of SLE patients from a single centre, to characterize such involvement, treatment modali...

journal_title：Autoimmunity reviews

authors： Toledano P,Orueta R,Rodríguez-Pintó I,Valls-Solé J,Cervera R,Espinosa G

更新日期：2017-07-01 00:00:00

abstract：:Immune thrombocytopenia (ITP) is a rare autoimmune disease due to an abnormal T cell response, notably supported by splenic T follicular helper cells, that stimulates the proliferation and differentiation of autoreactive B cells. The antiplatelet autoantibodies they produce facilitate platelet phagocytosis by macropha...

journal_title：Autoimmunity reviews

authors： Audia S,Mahévas M,Samson M,Godeau B,Bonnotte B

更新日期：2017-06-01 00:00:00

abstract：OBJECTIVE:Emerging data have shown an increased risk of malignancy among patients diagnosed with systemic sclerosis (SSc) so identification of risk factors linking both disorders might have prognostic implications. The aim of this study was to assess the clinical and treatment-related risk factors for cancer in a singl...

journal_title：Autoimmunity reviews

authors： Bernal-Bello D,de Tena JG,Guillén-Del Castillo A,Selva-O'Callaghan A,Callejas-Moraga EL,Marín-Sánchez AM,Fonollosa-Pla V,Simeón-Aznar CP

更新日期：2017-05-01 00:00:00

abstract：:Neonatal Lupus Syndrome (NLS) is a distinct clinical entity caused by transplacental passage of maternal anti-SSA/Ro antibodies (Ab). Mothers may have systemic lupus erythematosus, Sjögren syndrome, or other connective tissue disease, or may be completely healthy at the time of giving birth. NLS includes several clini...

journal_title：Autoimmunity reviews

authors： Zuppa AA,Riccardi R,Frezza S,Gallini F,Luciano RM,Alighieri G,Romagnoli C,De Carolis S

更新日期：2017-04-01 00:00:00

abstract：OBJECTIVE:This case control study assessed: 1) the relationship of systemic sclerosis (SSc) related to exposure to heavy metals; and 2) the risk of SSc related to occupational exposure in male and female patients. METHODS:From 2005 to 2008, 100 patients with a definite diagnosis of SSc were included in the study; 3 ag...

journal_title：Autoimmunity reviews

authors： Marie I,Gehanno JF,Bubenheim M,Duval-Modeste AB,Joly P,Dominique S,Bravard P,Noël D,Cailleux AF,Benichou J,Levesque H,Goullé JP

更新日期：2017-03-01 00:00:00

abstract：:Autoimmunity is increasingly accepted as the origin or amplifier of various diseases. In contrast to classic autoantibodies (AABs), which induce immune responses resulting in the destruction of the affected tissue, an additional class of AABs is directed against G-protein-coupled receptors (GPCRs; GPCR-AABs). GPCR-AAB...

journal_title：Autoimmunity reviews

authors： Becker NP,Müller J,Göttel P,Wallukat G,Schimke I

更新日期：2017-03-01 00:00:00

abstract：:The central function of the immune system is to protect the host from environmental agents such as microbes or chemicals, thereby preserving the integrity of the body, and preventing the onset of illness and infection. Moreover, the immune system is constantly challenged to discriminate self vs. non-self and mediate t...

journal_title：Autoimmunity reviews

authors： Dutra RC

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Steroid-responsive encephalopathy and associated autoimmune thyroiditis (SREAT) is characterized by encephalopathy and the presence of antithyroid antibodies. We describe the clinical presentation, outcome and treatments for SREAT by a systematic review of the literature. METHODS:MEDLINE via PubMed, Web of ...

journal_title：Autoimmunity reviews

authors： Laurent C,Capron J,Quillerou B,Thomas G,Alamowitch S,Fain O,Mekinian A

更新日期：2016-12-01 00:00:00

abstract：:The anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitides (AAV) are a heterogeneous group of diseases causing inflammation in small blood vessels and linked by the presence of circulating ANCA specific for proteinase 3 (PR3) or myeloperoxidase (MPO). These antigens are present both in the cytoplasmic granu...

journal_title：Autoimmunity reviews

authors： Brunini F,Page TH,Gallieni M,Pusey CD

更新日期：2016-11-01 00:00:00

abstract：:Anti-neutrophil cytoplasmic antibodies (ANCA) are a family of autoantibodies that react with proteins predominantly expressed in cytoplasmic granules of polymorphonuclear neutrophil granulocytes (PMNs). ANCA was initially detected using indirect immunofluorescence, allowing for different patterns such as p-ANCA (perin...

journal_title：Autoimmunity reviews

authors： Weiner M,Segelmark M

更新日期：2016-10-01 00:00:00

abstract：:The earliest experimental trials of monoclonal antibodies took place in the early 1980s using murine monoclonal antibodies directed at human lymphoma and leukemia cell antigens. Since those early trials, therapeutic advances have produced monoclonal antibodies and fusion proteins that are now used in multiple disease ...

journal_title：Autoimmunity reviews

authors： Schimizzi GF

更新日期：2016-09-01 00:00:00

abstract：:Autotaxin (ATX) is a 125-kD type II ectonucleotide pyrophosphatase/phosphodiesterase (ENPP2 or NPP2) originally discovered as an unknown "autocrine motility factor" in human melanoma cells. In addition to its pyrophosphatase/phosphodiesterase activities ATX has lysophospholipase D (lysoPLD) activity, catalyzing the co...

journal_title：Autoimmunity reviews

authors： Sun Y,Zhang W,Evans JF,Floreani A,Zou Z,Nishio Y,Qi R,Leung PS,Bowlus CL,Gershwin ME

更新日期：2016-08-01 00:00:00

abstract：:Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) constitutes a group of rare diseases characterized by necrotizing inflammation of small blood vessels and the presence of ANCA. Although these autoantibodies were initially used to classify pauci-immune vasculitis, increasing clinical and experimen...

journal_title：Autoimmunity reviews

authors： Jarrot PA,Kaplanski G

更新日期：2016-07-01 00:00:00

abstract：:Granulomatosis with polyangiitis (GPA) is an autoimmune systemic necrotizing small-vessel vasculitis associated with the presence of anti-neutrophil cytoplasmic antibodies (ANCA). Oto-neurological manifestations of ANCA-associated vasculitis according to PR3-ANCA positivity and MPO-ANCA positivity are usually reported...

journal_title：Autoimmunity reviews

authors： Iannella G,Greco A,Granata G,Manno A,Pasquariello B,Angeletti D,Didona D,Magliulo G

更新日期：2016-07-01 00:00:00

abstract：:Self-reactive antibodies represent a significant force in autoimmune disease induction. In antibody-dependent autoimmune syndromes such as immune thrombocytopenia (ITP), systemic lupus erythematosus (SLE), myasthenia gravis and rheumatoid arthritis (RA), autoantibodies exert their inflammatory effect through FcγRs, a ...

journal_title：Autoimmunity reviews

authors： Yu X,Lazarus AH

更新日期：2016-06-01 00:00:00

abstract：:As autoantibodies bind to target tissues, Fc-region dependent inflammation can induce pain via mediators exciting nociceptors. But recently another possibility has emerged, where autoantibody binding to nociceptors can directly cause pain, without inflammation. This is thought to occur as a result of Fab-region mediat...

journal_title：Autoimmunity reviews

authors： Goebel A

更新日期：2016-06-01 00:00:00

abstract：:Polyarteritis nodosa (PAN) is a systemic necrotizing vasculitis predominantly targeting medium-sized arteries. PAN is a rare form of vasculitis, and the precise frequency of this disease is difficult to determine. The major environmental factor associated with PAN is HBV infection. The pathogenesis of "idiopathic PAN"...

journal_title：Autoimmunity reviews

authors： De Virgilio A,Greco A,Magliulo G,Gallo A,Ruoppolo G,Conte M,Martellucci S,de Vincentiis M

更新日期：2016-06-01 00:00:00

abstract：:Autoimmune diseases refer to a spectrum of diseases characterized by an active immune response against the host, which frequently involves increased autoantibody production. The pathogenesis of autoimmune diseases is multifactorial and the exploitation of novel effective treatment is urgent. Capsaicin is a nutritional...

journal_title：Autoimmunity reviews

authors： Deng Y,Huang X,Wu H,Zhao M,Lu Q,Israeli E,Dahan S,Blank M,Shoenfeld Y

更新日期：2016-05-01 00:00:00

abstract：:Rett syndrome (RTT) is a devastating neurodevelopmental disease, previously included into the autistic spectrum disorders, affecting almost exclusively females (frequency 1:10,000). RTT leads to intellective deficit, purposeful hands use loss and late major motor impairment besides featuring breathing disorders, epile...

journal_title：Autoimmunity reviews

authors： De Felice C,Leoncini S,Signorini C,Cortelazzo A,Rovero P,Durand T,Ciccoli L,Papini AM,Hayek J

更新日期：2016-04-01 00:00:00

abstract：:Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by the loss of insulin-producing pancreatic β-cells. The pathogenesis of T1D is complex and multifactorial and involves a genetic susceptibility that predisposes to abnormal immune responses in the presence of ill-defined environmental insults to the ...

journal_title：Autoimmunity reviews

authors： Ferretti C,La Cava A

更新日期：2016-03-01 00:00:00

abstract：:The prevalence of ANA and anti-ENA in the general population is not well established, especially their clinical significance in healthy subjects. We herein determined the prevalence and predictive value of serum ANA and anti-ENA for connective tissue diseases (CTD), cancer, and mortality. We took advantage of a random...

journal_title：Autoimmunity reviews

authors： Selmi C,Ceribelli A,Generali E,Scirè CA,Alborghetti F,Colloredo G,Porrati L,Achenza MI,De Santis M,Cavaciocchi F,Massarotti M,Isailovic N,Paleari V,Invernizzi P,Matthias T,Zucchi A,Meroni PL

更新日期：2016-02-01 00:00:00

abstract：:Autoimmune diseases are characterized by the impaired function and the destruction of tissues that are caused by an immune response in which aberrant antibodies are generated and attack the body's own cells and tissues. Interleukin (IL) -37, a new member of the IL-1 family, broadly reduces innate inflammation as well ...

journal_title：Autoimmunity reviews

authors： Xu WD,Zhao Y,Liu Y

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Cardiac neonatal lupus syndrome is due to anti-SSA or SSB antibodies and mainly includes congenital heart block (CHB) and dilated cardiomyopathy (DCM). Its optimal management is still debated. We report a large series of autoimmune high degree CHB. METHODS:Inclusion criteria in this retrospective study were...

journal_title：Autoimmunity reviews

authors： Levesque K,Morel N,Maltret A,Baron G,Masseau A,Orquevaux P,Piette JC,Barriere F,Le Bidois J,Fermont L,Fain O,Theulin A,Sassolas F,Pezard P,Amoura Z,Guettrot-Imbert G,Le Mercier D,Georgin-Lavialle S,Deligny C,Hachull

更新日期：2015-12-01 00:00:00

abstract：:Since the earliest reports in 2001, immunoglobulin G4 (IgG4)-related disease has been defined as an autoimmune systemic disease characterized by the lymphoplasmacytic infiltration of affected tissues leading to fibrosis and obliterative phlebitis along with elevated serum IgG4 levels. Prior to this unifying hypothesis...

journal_title：Autoimmunity reviews

authors： Islam AD,Selmi C,Datta-Mitra A,Sonu R,Chen M,Gershwin ME,Raychaudhuri SP

更新日期：2015-10-01 00:00:00

abstract：:Posterior reversible encephalopathy syndrome is a rare clinicoradiological entity characterized by typical MRI findings located in the occipital and parietal lobes, caused by subcortical vasogenic edema. It was first described as a distinctive syndrome by Hinchey in 1996. Etiopathogenesis is not clear, although it is ...

journal_title：Autoimmunity reviews

authors： Granata G,Greco A,Iannella G,Granata M,Manno A,Savastano E,Magliulo G

更新日期：2015-09-01 00:00:00

abstract：:Type 1 diabetes (T1DM) is an autoimmune disease with aberrant immune responses to specific β-cell autoantigens, resulting in insulin deficiency. Children and adolescents with T1DM may also develop organ-specific multiple autoimmunity in the context of APS (autoimmune polyendocrine syndrome) type 1, 2 or 3. The most fr...

journal_title：Autoimmunity reviews

authors： Kakleas K,Soldatou A,Karachaliou F,Karavanaki K

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:Long-term anticoagulation is recommended in antiphospholipid syndrome with thrombosis in order to prevent recurrences. While the current mainstay relies on vitamin K antagonists, their long-term maintenance may remain challenging. OBJECTIVES:To report on the safety and the efficacy of oral direct inhibitors...

journal_title：Autoimmunity reviews

authors： Noel N,Dutasta F,Costedoat-Chalumeau N,Bienvenu B,Mariette X,Geffray L,Sene D,Chaidi RB,Michot JM,Fain O,Darnige L,Ankri A,Cacoub P,Piette JC,Saadoun D

更新日期：2015-08-01 00:00:00

abstract：:Group A Streptococcus (GAS) strains are lately classified on the basis of sequence variations in the emm gene encoding the M protein, but despite the high number of distinct emm genotypes, the spectrum of phenotypes varying from invasive suppurative to non-suppurative GAS-related disorders has still to be defined. The...

journal_title：Autoimmunity reviews

authors： Esposito S,Bianchini S,Fastiggi M,Fumagalli M,Andreozzi L,Rigante D

更新日期：2015-07-01 00:00:00

abstract：:Fecal calprotectin (FC) is a simple, non-invasive and reproducible test, which has been described to be highly elevated in patients with active inflammatory bowel diseases. Recently, few authors have reported increased levels of FC in SSc patients, although the relationship between FC levels and the degree of gastroin...

journal_title：Autoimmunity reviews

authors： Marie I,Leroi AM,Menard JF,Levesque H,Quillard M,Ducrotte P

更新日期：2015-06-01 00:00:00

abstract：:1,25-Dihydroxyvitamin D is a steroid hormone derived from vitamin D, playing an important role in maintaining an adequate serum level of calcium and phosphorus. It is now clear that vitamin D exerts an endocrine action on the cells of the immune system, generating anti-inflammatory and immunoregulatory effects. The me...

journal_title：Autoimmunity reviews

authors： D'Aurizio F,Villalta D,Metus P,Doretto P,Tozzoli R

更新日期：2015-05-01 00:00:00

abstract：:Approximately 500 treatment recalcitrant pemphigus vulgaris patients have been treated with rituximab. They were treated according to the lymphoma protocol (N=224) or rheumatoid arthritis protocol (RAP) (N=209) patients. Others were treated with modifications or combinations of the two. The mean duration of follow-up ...

journal_title：Autoimmunity reviews

authors： Ahmed AR,Shetty S

更新日期：2015-04-01 00:00:00